Proteasomes

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This book delves into proteasome structures and their connection to various aspects of proteasome function, emphasizing their crucial roles within the cell. It reveals the surprising fact that proteolysis is vital for cellular regulation, with sophisticated protease complexes, rather than lysosomes, controlling essential regulatory events. Proteasomes are implicated in numerous physiological functions, including the degradation of protein waste, antigen presentation, regulation of metabolism and differentiation, and control of the cell cycle. The discovery of these diverse and critical roles has made proteasome-mediated regulatory proteolysis a significant focus in cell biology. Authored by pioneers in the field, the book provides a comprehensive and current perspective on proteasome structures and functions, linking all facets of cell function. It serves as an essential resource for scientists in basic and applied cell biology and immunology. Additionally, the book discusses how various aspects of proteasome functions relate to serious diseases such as cancer, neurodegeneration, cystic fibrosis, and immune disorders. Consequently, the information presented is valuable for physicians, pharmacologists, and experts in the pharmaceutical industry engaged in research.