Erik De Clercq Livres

Proč přesně, chemie a medicína? Autor této knihy, prof. Erik De Clercq, ve svých přednáškách představuje nádherný svět na pomezí (bio)chemie a moderní medicíny. Zdůraznil například biosyntézu nukleotidů, porfyrinů, hemu, hemoglobinu, cholesterolu, žlučových kyselin, CO, NO, roli karboxylových kyselin, močoviny a dalších cyklů, patologii diabetu, dny a dalších metabolických onemocnění, roli enzymů, hormonů, vitamínů, antibiotik a antivirotik. Cílem celého pojednání je okouzlit čtenáře bez ohledu na věk či původ krásou (bio)chemie při dobývání lidského zdraví. Why precisely, chemistry and medicine? Author of this book, Prof. Erik De Clercq, in his lectures presents a wonderful world on the border of (bio)chemistry and modern medicine. He has highlighted, for instance, the biosynthesis of nucleotides, porphyrins, heme, hemoglobine, cholesterol, bile acids, CO, NO, the role of the carboxylic acids, urea and other cycles, the pathology of diabetes, gout and other metabolic diseases, the role of enzymes, hormones, vitamins, antibiotics and antivirals. The aim of the whole treatise is to enchant the readers, whatever their age or background, with the beauty of (bio)chemistry at the conquest of human health.

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.

An extensive assessment of combination therapy of AIDS. Main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. The chapters cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology. The volume closes with an outlook on future perspectives.