Cette série plonge dans les profondeurs de l'espace, où l'humanité établit le premier contact avec une intelligence extraterrestre par le biais de signaux mystérieux. Les connaissances découvertes, déchiffrées à partir d'un ordinateur extraterrestre, ouvrent une boîte de Pandore de la compréhension humaine. La science et la technologie sont poussées à leurs limites, mais elles font également face à une menace qui pourrait compromettre la simple existence de l'humanité.
A new radio telescope picks up from the constellation of Andromeda a complex series of signals which prove to be a programme for a giant computer. After the computer is built it begins to relay information from Andromeda. Scientists find themselves possessing knowledge previously unknown to mankind, knowledge that could threaten the security of human life itself.
The Andromeda Breakthrough is a sequel to the popular BBC TV science fiction serial A for Andromeda, written by Fred Hoyle and John Elliot. Kidnapped by Intel, John Fleming, the hero of the first serial, and Andromeda, the artificially constructed human, are brought to Azaran, a small Middle Eastern country, where a duplicate of the machine he designed has been built by Intel. After many dangers, he finds both the reason for the original message having been sent and the means to bring the machine under human control.