Matthias Beller Livres

Transition Metal Catalyzed Carbonylation Reactions is a comprehensive monograph focusing on carbon monoxide usage. This book provides students and researchers in organic synthesis with a detailed discussion of carbonylation from the basics through to applications. The authors have structured the book around the types of reactions, based on the different nucleophiles involved. Scientists working in carbonylation or with carbon monoxide, as well as teachers of organic synthesis can use this book to become familiar with this important area of organic chemistry.

Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.

Carbonylation reactions are of major importance in both organic and industrial chemistry. Due to the availability, price and reactivity pattern, carbon monoxide is becoming a more and more important building block for fine and bulk chemicals. The major reaction types of carbon monoxide are comprehensively discussed by leading experts from academia and industry. The authors highlight important carbonylation reactions such as hydroformylation, alkoxy-carbonylations, co/olefin-copolymerization, Pauson-Khand reactions and others. They illustrate applications in organic synthesis and give industrial examples. This volume is designed to provide graduate students and researchers with essential information on the use of carbon monoxide in organic synthesis. Therefore, the reader will get a balanced view of this developing and complex subject.