Anthony J. Burke Livres

The full story of the last sword designed by a major power for its army to use as a weapon, not as an article of a dress uniform.

Uranium, the most atomically unstable natural element on earth, has a unique place in the global geopolitics of resources. It provides energy to millions of people and its isotopes are used to power spacecraft and in nuclear medicine.

This book presents effective catalytic reactions, emphasizing process intensification, sustainability, waste reduction, and innovative methods crucial for producing pharmaceutically active molecules. It highlights key catalytic reactions and efficient processes, showcasing their advantages over traditional methods. A strong focus is placed on asymmetric catalytic reactions, continuous manufacturing processes, and supported catalysis. Chapters include topics such as the prerequisites for the modern pharmaceutical industry, catalytic process design from an industrial perspective, and various catalytic reactions, including hydrogenation, hydroformylation, oxidation, addition, cross-coupling, metathesis, cycloaddition, cyclopropanation, C-H insertion, phase transfer catalysis, and biocatalysis. The book provides an updated view of the catalysis landscape for API production, focusing on the application of catalytic methods for synthesizing known APIs. It covers key reactions like Diels-Alder and metal-catalytic coupling, and includes recent patent literature for thoroughness. This resource is essential for synthetic chemists and R&D researchers in the pharmaceutical industry, making it a must-read for those involved in API synthesis.

This "hands-on" approach to the topic of arylation consolidates the body of key research over the last ten years (and up to around 2014) on various catalytic methods which involve an arylation process. Clearly structured, the chapters in this one-stop resource are arranged according to the reaction type, and focus on novel, efficient and sustainable processes, rather than the well-known and established cross-coupling methods. The entire contents are written by two authors with academic and industrial expertise to ensure consistent coverage of the latest developments in the field, as well as industrial applications, such as C-H activation, iron and gold-catalyzed coupling reactions, cycloadditions or novel methodologies using arylboron reagents. A cross-section of relevant tried-and-tested experimental protocols is included at the end of each chapter for putting into immediate practice, along with patent literature. Due to its emphasis on efficient, "green" methods and industrial applications of the products concerned, this interdisciplinary text will be essential reading for synthetic chemists in both academia and industry, especially in medicinal and process chemistry.