Daniele Focosi Livres

The book delves into the genetic traits and structural changes of SARS-CoV-2 variants circulating globally, focusing on their evolution across different regions during the pandemic. It examines the implications of these mutations on the effectiveness of existing neutralizing antibody-based vaccines and treatments, supported by recent clinical data. Additionally, the author proposes strategies to mitigate immune escape in future COVID-19 therapies, providing a comprehensive understanding of the ongoing challenges posed by these viral variants.

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.