Mohamed Al-Rubeai Livres

Engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials and their total worldwide sales continue to increase significantly. The importance of antibody applications is reflected in their increasing clinical and industrial applications as well as in the progression of established and emerging production strategies. This volume provides detailed coverage of the generation, optimization, characterization, production and applications of antibody. It provides the necessary theoretical background and description of methods for the expression of antibody in microbial and animal cell cultures and in transgenic animals and plants. There is a strong focus on those issues related to the production of intrabodies, bispecific antibody and antibody fragments and also to novel applications in cancer immunotherapy.

The editors of this special volume express gratitude to all authors for their outstanding contributions and acknowledge Prof. Dr. Thomas Scheper, Dr. Marion Hertel, and Ulrike Kreusel for enabling this project, along with Springer for their organizational support. Tissue engineering is a rapidly evolving field within modern biotechnology, integrating biological and material sciences with engineering and clinical disciplines. Its primary goal is to develop therapeutic strategies to replace or enhance the function of diseased organs or tissues. This involves using three-dimensional biocompatible materials seeded with cells and cultivated in appropriate systems to create functional tissues. Key factors in forming these 3D structures include the source of cells, with autologous cells being preferred to minimize rejection and immune responses. Stem cells, in particular, are crucial as they can be differentiated into various tissues through specific media and supplements. In biomaterials, a variety of scaffold materials are available, and new composites are being developed from polymeric, natural, or xenogenic sources. Additionally, the controlled formation of tissues under reproducible conditions is essential, leading to the development of numerous innovative bioreactors.

The aim of this volume is to provide an in-depth overview of the state-of-the-art research on apoptosis with contributions from key groups working in the field. This type of programme cell death has received wide and rapid attention and now is considered as one of the hottest areas of science. The volume covers various aspects of the apoptotic death process from the morphological and biochemical features, mechanisms and genetic regulation to its role in pathological process and potential implications for biomedical research and biopharmaceutical production.

Bioprocess and Algae Reactor Technology Apoptosis Advances in Biochemical Engineering Biotechnology Volume 59