In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact.Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis.The Black Box of Biology shows that what led to the incredible transformation of biology was not a simple accumulation of new results, but the molecularization of a large part of biology. In fact, Morange argues, the greatest biological achievements of the past few decades should still be understood within the molecular paradigm. What has happened is not the displacement of molecular biology by other techniques and avenues of research, but rather the fusion of molecular principles and concepts with those of other disciplines, including genetics, physics, structural chemistry, and computational biology. This has produced decisive changes, including the discoveries of regulatory RNAs, the development of massive scientific programs such as human genome sequencing, and the emergence of synthetic biology, systems biology, and epigenetics.Original, persuasive, and breathtaking in its scope, The Black Box of Biology sets a new standard for the history of the ongoing molecular revolution.
Matthew Cobb Livres






As Gods
- 464pages
- 17 heures de lecture
The thrilling and terrifying history of genetic engineering In 2018, scientists manipulated the DNA of human babies for the first time. As biologist and historian Matthew Cobb shows in As Gods, this achievement was one many scientists have feared from the start of the genetic age. Four times in the last fifty years, geneticists, frightened by their own technology, have called a temporary halt to their experiments. They ought to be frightened: Now we have powers that can target the extinction of pests, change our own genes, or create dangerous new versions of diseases in an attempt to prevent future pandemics. Both awe-inspiring and chilling, As Gods traces the history of genetic engineering, showing that this revolutionary technology is far too important to be left to the scientists. They have the power to change life itself, but should we trust them to keep their ingenuity from producing a hellish reality?
The Idea of the Brain
- 480pages
- 17 heures de lecture
Shortlisted for the 2020 Baillie Gifford PrizeThis is the story of our quest to understand the most mysterious object in the universe: the human brain.Today we tend to picture it as a computer. Earlier scientists thought about it in their own technological terms: as a telephone switchboard, or a clock, or all manner of fantastic mechanical or hydraulic devices. Could the right metaphor unlock the its deepest secrets once and for all?Galloping through centuries of wild speculation and ingenious, sometimes macabre anatomical investigations, scientist and historian Matthew Cobb reveals how we came to our present state of knowledge. Our latest theories allow us to create artificial memories in the brain of a mouse, and to build AI programmes capable of extraordinary cognitive feats. A complete understanding seems within our grasp.But to make that final breakthrough, we may need a radical new approach. At every step of our quest, Cobb shows that it was new ideas that brought illumination. Where, he asks, might the next one come from? What will it be?
A gripping and insightful history of the French Resistance and the men and women who opposed Nazi occupation during World War II.
Smell: A Very Short Introduction
- 168pages
- 6 heures de lecture
Matthew Cobb explores the sense of smell - its complex evolutionary history, and its many functions in a wide variety of animals, including humans. He describes the latest scientific research into this remarkable faculty, involving the brain as much as the nose, and reveals surprising insights into animal and human life.
Life's Greatest Secret
- 448pages
- 16 heures de lecture
This thrilling account shows how discovering DNA has fundamentally influenced the way we think of life and affected every aspect of our lives. Now available in paperback.
Eleven Days in August
- 544pages
- 20 heures de lecture
A gripping day by day account of the liberation of Paris from the Nazis in August 1944
Chociaż może się to nam wydawać zaskakujące, pojęcie kodu przenoszącego informację genetyczną pojawiło się dopiero 1953 r.Wprowadzili je James Watson i Francis Crick, w artykule opublikowanym w czasopiśmie ?Nature?. Idea została bez zastrzeżeń zaakceptowana przez świat naukowy, chociaż nikt jeszcze nie wiedział, w jaki spos�b może działać �w tajemniczy kod, złożony z cząstek czterech zasad, łączących nici DNA w podw�jną helisę.Książka Matthew Cobba, genetyka i historyka, opowiada o niezwykłych źr�dłach tych koncepcji, kt�rych początki można odnaleźć w matematyce, fizyce, a także badaniach nad systemami łączności.Autor pokazuje, w jaki spos�b idee dotyczące informacji przeniknęły do biologii za pośrednictwem cybernetyki, umożliwiając naukowcom zrozumienie istoty kodu genetycznego