Pierre Jolle s. Livres

New technological innovations create an almost unlimited array of domains in which drugs can act with increasing precision and less side-effects. Novel tools give concise insights into gene, membrane and protein interactions leading to the development of specific 'tailor-made' drugs. New Approaches to Drug Development reviews latest discoveries in drug research and highlights some of the many therapeutic possibilities whose growing applications can only be estimated in part. This profound and extensive documentation of novel findings and outlooks in drug development and delivery systems contains contributions of leading scientists in the fields of genetics and molecular biology, pharmacology, genetic engineering and psychiatry. Many of their evaluations are not just restricted to specific diseases, but encompass infections, coronary syndromes and syndromes associated with dysfunctions on the genetical, cellular, physiological and metabolic level in general.

A wealth of information has accumulated over the last few years on the human genome. The new insights have completely changed the focus of protein analysis. It is no longer time-consuming analysis of unknown products, but rather selective identifications of individual forms, modifications and processings, and overall analysis of global protein outputs from cells and tissues in health and disease. This book gears to the rising need of sensitive, accurate, and fast separation and identification techniques in proteomics. It discusses current methodologies of modern protein analysis, from isolation and sample preparation, over analysis and identification, to final characterization. Several evaluations concentrate on the now productive approaches of two-dimensional gel electrophoresis and mass spectrometry, but alternative methods and further perspectives are also outlined. The book includes an overlook over current databases to connect protein analysis data with all available information,...