Modification of tumor development in rodents

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Human cancer is now generally accepted as being primarily the result of a multitude of interacting environmental factors. This study offers coverage of the ability of exogenous influences to modify tumourigenesis in the organs most often involved in cancer. The first theoretical section highlights the principles now thought to underlie neoplasia in rodents and how they can be applied to in vivo risk assessment. In the second section, experienced researchers discuss the modification of tumour development in the gastrointestinal tract, liver, pancreas, lung, urinary bladder, breast and skin. Both endogenous and exogenous influences and their possible interactions are considered, with emphasis placed on dietary and other factors relevant to the human situation.