Genetics of asthma and atopy

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Allergic disease is caused by exposure of genetically predisposed individuals to sensitizing agents. Presenting current reviews on the genetics of asthma and atopy, this volume aims to increase the understanding of the mechanisms underlying this predisposition. It includes general reviews on the role of genetic factors as well as articles specifically dealing with candidate genes or candidate loci likely to be important in the etiology of allergic disease. Other chapters deal with the genetics of airway responsiveness in animal models and work examining the linkage between HLA genotypes and allergic disease. Special attention is given to the role of genes on 11q (including the high affinity IgE receptor) in the development of allergic disease and the contribution of genes on 5q (including TH2 cytokine genes and the [beta][subscript 2]-adrenoceptor gene) to the asthma phenotype. A compilation of exciting up-to-date information, this book is ideal for clinicians and basic scientists wishing to keep track of the latest findings in this challenging and fast-moving field.