Dehydroepiandrosterone (DHEA)

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This comprehensive collection explores the biological effects and potential therapeutic applications of Dehydroepiandrosterone (DHEA). It begins with a review of DHEA's biological impacts, followed by an examination of its possible anti-aging effects linked to caloric restrictions. The role of DHEA in cytokine dysregulation associated with aging and AIDS is discussed, alongside its influence on the aging immune system. The restoration of immunocompetence in aging and inflammatory diseases through DHEA-3ß-sulfate is also highlighted. The anti-obesity effects of DHEA are explored through clinical studies, mechanisms of action, and its relationship with cardiovascular disease. The implications of DHEA in carcinogenesis, particularly hepatocarcinogenesis, are examined, detailing both the induction of neoplasms and the biochemical changes during neoplastic development. Neuropsychiatric effects and the intricacies of DHEA metabolism in various species are discussed, alongside its role as a precursor of androgens and estrogens. The collection also addresses DHEA's impact on liver function, mitochondrial respiration, and osteoblastic activities. Finally, interactions between DHEA and dexamethasone in lymphocyte proliferation and its relation to stress reactions are presented, providing a holistic view of DHEA's multifaceted roles in health and disease.