Extra cellular matrix in the craniofacial complex

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The extracellular matrix (ECM) constitutes the solid-phase microenvironment of cells and harbors a myriad of structural proteins whose complex functions are now beginning to be unraveled. The papers presented in this issue reveal novel concepts about the role of the ECM in controlling the structure, strength and function of the head and face. Emphasis is placed on understanding the mechanisms of ECM action as it relates to growth factor distribution and function as well as matrix microarchitecture. Authors discuss the contextual background, new data and perspectives for future work using experimental systems employing animal models, new tools for cell biology and imaging, molecular profiling and nanotechnology. The new findings presented in this issue illustrate how our current concept of the ECM in craniofacial biology has been ‘reinvented’ and integrates multiple fields focusing on suture biology, mineralization, tooth development and temporomandibular joint form and function. Basic scientists interested in matrix biology, dentists and physicians interested in development and function of the head and face, as well as students seeking an orientation to ECM and craniofacial biology will appreciate the up-to-date information provided in this publication.