IgA nephropathy today

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Primary IgA nephropathy, identified nearly 40 years ago, is an immune-complex-mediated glomerulonephritis marked by granular deposits of IgA (primarily IgA1) and C3 in the glomerular mesangial areas. This condition is characterized by proliferative changes in glomerular mesangial cells and an increase in mesangial matrices. It ranks as one of the most prevalent forms of chronic glomerulonephritis and is a leading cause of end-stage renal disease. Despite ongoing research clarifying various aspects of its pathogenesis, no specific treatment is currently available. This publication features contributions from international nephrologists and basic scientists, presenting the latest findings on IgA nephropathy. It begins with clinical reviews covering topics like clinico-pathological classification, novel treatment strategies, and the significance of renal biopsies. The focus then transitions to basic reviews discussing candidate genes, the role of IgA receptors, and immune complex formation. The second part of the book provides updates on clinical and basic advances, including the impact of obesity and various therapeutic approaches. This comprehensive resource offers valuable insights for nephrologists, general practitioners, residents, and interns seeking to understand this complex disease.