Cascade biocatalysis

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This ready reference presents environmentally friendly and stereoselective methods of modern biocatalysis, compiled by a renowned team of editors and top international authors. It explores emerging topics such as chemoenzymatic methods and multistep enzymatic reactions, demonstrating practical applications of these innovative concepts. The book covers multidisciplinary subjects, including directed evolution, dynamic kinetic resolution, and continuous-flow methodology. Key topics include directed evolution of ligninolytic oxidoreductases, in situ enzymatic recycling of NAD(P)(H) cofactors, and monooxygenase-catalyzed redox cascade biotransformations. It also discusses biocatalytic redox cascades involving w-transaminases, multi-enzyme systems with cytochrome P450 monooxygenases, and chemo-enzymatic cascade reactions for synthesizing glycoconjugates. Further insights include the synergies of chemistry and biochemistry for producing beta-amino acids, racemizable acyl donors for enzymatic dynamic kinetic resolution, and stereoselective hydrolase-catalyzed processes in continuous-flow mode. Additional topics encompass perspectives on multienzyme process technology, nitrile-converting enzymes in cascade reactions, and the enzymatic stereoselective synthesis of beta-amino acids, among others. This comprehensive resource is essential for anyone interested in the latest advancements in biocatalysis.