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This is an analysis of morbidity and treatment of data, including time trends, in England and Wales. This report presents statistics from general practice which offer a source of information about public health issues, including disease prevalence and the demand for health care. The report is the third in a series of morbidity and treatment data derived from the General Practice Research Database. The database holds anonymized patient-based clinical records submitted regularly by general practices. Data from 211 practices and 1.4 million patients are analyzed here, representing 2.6 per cent of the population in England and Wales.