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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Langue
- Année de publication
- 2014
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- (souple)
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- Sous-titre
- Synthesis and Biological Evaluation
- Langue
- Anglais
- Auteurs
- Colm Duffy
- Éditeur
- Springer, Berlin
- Publié
- 2014
- Format
- souple
- Pages
- 152
- ISBN13
- 9783642438929
- Séries
- Springer Theses
- Mots clés
- Nonfiction
- Description
- Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.