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The book presents a green and efficient one-pot microwave irradiation method for synthesizing quinoline-4-carboxylic acids using the non-hazardous p-TSA catalyst. This protocol boasts high product yields and purity, significantly reduced reaction times, and eliminates hazardous solvents, aligning with green chemistry principles. It details the synthesis of compounds 4a-4p and their biological activity testing, with molecular docking studies indicating their compatibility with protein active sites. Compound 4c was highlighted for further molecular dynamics analysis.
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Application and Synthesis of Small Quinoline Derivatives, Dhaval B. Patel
- Langue
- Année de publication
- 2023
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- Titre
- Application and Synthesis of Small Quinoline Derivatives
- Sous-titre
- DE
- Langue
- Anglais
- Auteurs
- Dhaval B. Patel
- Éditeur
- Scholars' Press
- Publié
- 2023
- Format
- souple
- Pages
- 64
- ISBN13
- 9786205521984
- Séries
- Mots clés
- Nonfiction, Science et Mathématiques, Sciences naturelles, Chimie
- Description
- The book presents a green and efficient one-pot microwave irradiation method for synthesizing quinoline-4-carboxylic acids using the non-hazardous p-TSA catalyst. This protocol boasts high product yields and purity, significantly reduced reaction times, and eliminates hazardous solvents, aligning with green chemistry principles. It details the synthesis of compounds 4a-4p and their biological activity testing, with molecular docking studies indicating their compatibility with protein active sites. Compound 4c was highlighted for further molecular dynamics analysis.