Selenium, Selenoprotein coding genes and CHEK2-dependent cancers

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The research highlights the significant correlation between higher selenium concentrations and a reduced likelihood of cancer detection, particularly in individuals with CHEK2 mutations who are at increased risk. Additionally, specific genetic variations in TXNDR2 and SEP15 may further aid in assessing cancer risk among these carriers. The findings suggest that serum selenium levels could serve as a valuable marker for identifying individuals who may benefit from surveillance procedures like CT scans or colonoscopies, especially for early detection of bronchial and colorectal cancers. Further studies are needed to explore the impact of selenoprotein gene variations on cancer risk.