Transport by proteins

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This comprehensive work delves into various aspects of protein-ligand interactions, transport mechanisms, and the thermodynamics underlying these processes. It begins with an exploration of thermodynamics related to protein-ligand interactions and classifications of transport mechanisms through non-equilibrium thermodynamics. The investigation of membrane processes is further enhanced by chemical relaxation spectrometry and NMR studies of glycolysis in E. coli. The text then focuses on selected transport proteins, discussing serum albumin's role, intracellular binding proteins like ligandin and protein A, and the absence of heme-heme interactions in hemoglobin. It also examines multi-enzyme complexes, redox-transport modes, and energy transduction mechanisms in photophosphorylation. Subsequent sections cover proteins involved in mitochondrial calcium transport, the dynamics of proton transfer in bacteriorhodopsin, and the impact of cholesterol on mediated transport systems. The role of ion channels in excitable membranes is also highlighted. Metal transport by proteins is addressed, detailing ferritin's iron deposition, thermodynamic factors in iron binding to transferrin, and heme transport properties. A genetic defect in copper transport related to Wilson's disease is discussed. Finally, the physiological and pharmacological implications of protein transport are examined, including drug-binding properties of serum albumi