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For years, a perfectly preserved mummy lay forgotten in the basement of Boston’s Crispin Museum until its rediscovery by staff sparked intrigue and excitement. Known as “Madam X,” this ancient Egyptian artifact appears to be a boon for the financially struggling museum. However, medical examiner Maura Isles uncovers a horrifying truth: the mummy is not an ancient relic but a modern murder victim. Alongside Boston homicide detective Jane Rizzoli, she faces unsettling forensic evidence that indicates a serial killer is at work. The discovery of another woman's remains within the museum heightens their urgency as the killer begins to taunt them. Archaeologist Josephine Pulcillo feels a chilling connection when cryptic messages from the murderer surface, and her dread intensifies when a third victim's corpse is left in her car, hinting at a personal vendetta. The killer’s knowledge of post-mortem rituals suggests a disturbing link to Josephine, who harbors a dark secret. As Maura draws on her expertise in ancient death traditions to decipher the killer's motives, Josephine’s sudden disappearance adds to the urgency. With time running out, Maura and Jane must thwart the Archaeology Killer before he claims another victim.