Focusing on the interconnectedness of inflammation and cancer, this book presents a comprehensive exploration of both diseases, particularly in the gastrointestinal tract and liver. It features contributions from basic scientists and clinicians worldwide, offering insights into the latest research on pathogenesis and treatment strategies. By discussing potential pathogenic modulators and therapeutic options, the work aims to enhance understanding of these prevalent conditions, making it a valuable resource for researchers and healthcare professionals alike.
Excessive alcohol consumption and smoking are major cancer risk factors, with their simultaneous use further elevating the risk for cancers of the upper aerodigestive tract due to various metabolic and genetic interactions. The first part of this book explores the links between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas, and breast. It discusses how alcohol impairs methionine-folate metabolism and DNA methylation, and examines the potential of s-adenosylmethionine in cancer prevention. Additionally, it addresses the synergistic effects of reactive oxygen species and iron in liver cancer development. The second part focuses on tobacco's role in lung and digestive tract cancers, emphasizing prevention strategies and the impact of phytochemicals. It details the mutagenic, mitogenic, precarcinogenic, anti-apoptotic, and immunosuppressive effects of nicotine in cancer development, along with the potential of a nicotine vaccine to reduce tobacco-related mortality. By highlighting mechanisms that lead to cancer and providing insights into how alcohol and tobacco promote carcinogenesis, this book serves as a valuable resource for those interested in the subject.
